There are multiple studies examining both the efficacy and safety of phosphate binders. It is evident that all phosphate binders are efficacious at reducing phosphate levels. However, there are no randomized controlled trials showing one agent is superior to the others in terms of phosphate binding. There are trials comparing safety, specifically which agents lead to an increased risk of vascular calcification and a potential increased risk of mortality. Click on the links below to access a summary of the trials and relevant results.
CARE study
Treat to Goal Study
RIND
RIND Outcome
DCOR
Magnesium Carbonate - Calcium Carbonate Combination
CARE study
Treat to Goal Study
RIND
RIND Outcome
DCOR
Magnesium Carbonate - Calcium Carbonate Combination